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KMID : 0380620140460020219
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Korean Journal of Food Science and Technology
2014 Volume.46 No. 2 p.219 ~ p.223
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Protective Effects of Fucoidan against Acute Alcohol-induced Liver Injury in Rats
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Kim Mi-Ja
Jeon Joseph
Lee Sung-Pyo
Lee Jin-Sil
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Abstract
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The purpose of this study was to investigate the protective effects of fucoidan on acute alcohol-induced liverinjury in rats. Experimental animals were randomly divided into four groups: (1) a control group, (2) a group fed 25%ethanol, (3) a group fed 25% ethanol and 250 mg/kg BW of fucoidan (25% ethanol+FUCO250), and (4) a group fed 25%ethanol and 500 mg/kg BW of fucoidan (25% ethanol+FUCO500). Each group was fed orally two times per day for 15days. Liver weights in the 25% ethanol group were increased compared to the control group, while liver weights in the25% ethanol+FUCO500 group were significantly decreased compared to the 25% ethanol group (p<0.05). Plasmaconcentrations of triglyceride, cholesterol, and LDL-cholesterol were elevated in the 25% ethanol group; however, theselevels in the 25% ethanol+FUCO250 group were significantly decreased compared to the 25% ethanol group (p<0.05). Theglutamic-pyruvic transaminase activity of the 25% ethanol+FUCO500 group also was significantly lower than the 25%ethanol group (p<0.05). These results indicate that fucoidan might protect against acute alcohol-induced liver injury.
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KEYWORD
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acute alcohol injury, fucoidan, glutamic-pyruvic transaminase, liver injur
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